United qualified as Group A runners-up and were paired with Christophe Galtier’s team, who beat Anderlecht in their final Group C game to pip the Belgian outfit to top spot.
Tottenham were handed the short trip to Belgium to face Group H runners-up Gent, who qualified by winning their final match against Konyaspor.
United boss Jose Mourinho welcomed the short trip to France after a Group A campaign which saw his side travel to Turkey and Ukraine to face Fenerbahce and Zorya Luhansk respectively.
“The good thing is the travel,” he told manutd.com. “We were very unlucky in the group stage… now we go to France.”
The tie pits United’s Paul Pogba, the world’s most expensive player, against his brother Florentin who plays in Les Verts’ defence.
“It’s nice, it’s a nice thing,” said Mourinho. “Paul will be laughing, and for sure his brother will also be laughing.
“I think it’s nice, it’s happened in the history of football a few times and it’s nice.”
Florentin Pogba posted a split-screen picture on Instagram of himself and his brother, captioned: “POGBA (v) POGBA #thankgod #lapogbance #6 #19 #asse(v)manutd #uel”
Full draw:
Athletic Bilbao vs. Apoel FC
Legia Warsaw vs. Ajax
Anderlecht vs. FC Zenit
Astra Giurgiu vs. Genk
Manchester United vs. Saint-Etienne
Villarreal vs. AS Roma
Ludogorets Razgrad vs. FC Copenhagen
Celta Vigo vs. Shakhtar Donetsk
Olympiacos vs. Osmanlispor
Gent vs. Tottenham Hotspur
FC Rostov vs. Sparta Prague
FC Krasnodar vs. Fenerbahce
Borussia Moenchengladbach vs. Fiorentina
AZ Alkmaar vs. Lyon
Hapoel Beer-Sheva vs. Besiktas
PAOK vs. Schalke
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